Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles

Citations Over TimeTop 10% of 2009 papers

Abstract

Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve the dual roles as effective reducing agents to reduce gold and also as stabilizers to provide robust coating on the gold nanoparticles in a single step. The Tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and have been found to be non toxic as assessed through MTT assays. No 'man made' chemicals, other than gold salts, are used in this true biogenic green nanotechnological process thus paving excellent opportunities for their applications in molecular imaging and therapy.

Related Papers

• → Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives(2013)24 cited
• Anti Oxidant Potential of “Cureit”- A Novel BioAvailable Curcumin Formulation(2014)
• → Metabolic Fate of Curcumin in the Gastrointestinal Tract in Mice(2016)1 cited
• → Plasma concentrations of curcumin in individuals using curcumin with adjuvants or lipid formulated curcumin supplements: a real world cohort(2023)2 cited
• → Evaluation of Curcumin Nanoparticles against Rabbit Skin Infection(2023)