Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition
Chemical Communications2009Vol. 46(1), pp. 97–99
Citations Over TimeTop 1% of 2009 papers
Marjoke F. Debets, Sander S. van Berkel, Sanne Schoffelen, Floris P. J. T. Rutjes, Jan C. M. van Hest, Floris L. van Delft
Abstract
A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.
Related Papers
- → The Impact of PEGylation on Biological Therapies(2008)1,010 cited
- → PEGYLATION: an important approach for novel drug delivery system(2020)144 cited
- → Pegylation and Its Impact on the Design of New Protein-Based Medicines(2014)89 cited
- → Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone(2017)46 cited
- 포스터발표 2 : 생명공학 ; P-437 : 재조합 인터페론-알파-2a의 재생을 위한 고체상 PEGylation과 재접힘의 통합 공정(2007)