Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems
Chemical Communications2010Vol. 46(20), pp. 3547–3547
Citations Over TimeTop 13% of 2010 papers
Abstract
A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.
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