Co(iii)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: a concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone
Chemical Communications2010Vol. 46(27), pp. 5012–5012
Citations Over TimeTop 16% of 2010 papers
R. Santhosh Reddy, Pandurang V. Chouthaiwale, Gurunath Suryavanshi, Vilas B. Chavan, Arumugam Sudalai
Abstract
The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S,S)-reboxetine and (+)-epi-cytoxazone.
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