Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles
Chemical Communications2010Vol. 46(42), pp. 8064–8064
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Liang‐Liang Wang, Liang‐Liang Wang, Lin Peng, Jian‐Fei Bai, Qingchun Huang, Xiao‐Ying Xu, Li-Xin Wang, Li-Xin Wang
Abstract
An efficient Michael-ketone aldol-dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
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