Preparation of benzolactams by Pd(ii)-catalyzed carbonylation of N-unprotected arylethylamines
Chemical Communications2010Vol. 47(3), pp. 1054–1056
Citations Over TimeTop 10% of 2010 papers
Abstract
An unprecedented NH(2)-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield 6-membered benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.
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