Coumarin–malonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular expression
Chemical Communications2010Vol. 47(6), pp. 1773–1775
Citations Over TimeTop 1% of 2010 papers
Abstract
A nonfluorescent coumarin-malonitrile conjugate (1) was transformed into a strongly fluorescent molecule through the Michael addition of a thiol group to the α,β-unsaturated malonitrile of 1. The molecular probe has exhibited a highly selective fluorescence response toward biothiols (Cys, Hcy, GSH) with micromolar sensitivity both in vitro and in vivo.
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