Tailoring nanocarriers for intracellular protein delivery
Citations Over TimeTop 10% of 2011 papers
Abstract
Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein delivery using various nanocarriers. Methods such as lipid-mediated colloidal systems, polymeric nanocarriers, inorganic systems and protein-mediated carriers are reviewed. Advantages and limitations of current strategies, as well as future opportunities and challenges are also discussed.
Related Papers
- → Delivery of Doxorubicin Using Double-Layered Core–Shell Nanocarrier Based on Magnetic Fe3O4 Core and Salep Shells(2018)20 cited
- → An Analysis of the Capturing and Passing Ability of a DNA Origami Nanocarrier with the Aid of Molecular Dynamics Simulation(2022)7 cited
- → The emergence of nanocarriers in the management of diseases and disorders(2023)5 cited
- → General justification in terms of effectiveness and toxicities for the use of nanocarriers(2023)3 cited
- → Strategies for ligand-installed nanocarriers(2021)2 cited