Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Chemical Communications2012Vol. 48(40), pp. 4839–4839
Citations Over TimeTop 10% of 2012 papers
Andrea Kurzwernhart, Wolfgang Kandioller, Caroline Bartel, Simone Bächler, Robert Trondl, Gerhard Mühlgassner, Michael A. Jakupec, Vladimir B. Arion, Doris Marko, Bernhard K. Keppler, Christian G. Hartinger
Abstract
Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
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