α-Amination of keto-nitrones via Multihetero-Cope rearrangement employing an imidoyl chloride reagent
Chemical Communications2012Vol. 48(61), pp. 7568–7568
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Abstract
α-Aminations of ketone-derived nitrones have been developed via [3,3]-rearrangement of the intermediates generated upon condensation with imidoyl chlorides. Careful reagent selection provides synthetically attractive amino protecting groups. The enediamide or α'-carbamoyl enamide products can be hydrolyzed to the desired carbonyl, or exposed to electrophiles for further α-functionalization.
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