Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery
Chemical Communications2012Vol. 48(96), pp. 11781–11781
Citations Over TimeTop 10% of 2012 papers
Thomas‐Xavier Métro, Julien Bonnamour, Thomas Reidon, Jordi Sarpoulet, Jean Martínez, Frédéric Lamaty
Abstract
The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.
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