Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs
CrystEngComm2011Vol. 14(7), pp. 2377–2380
Citations Over TimeTop 10% of 2011 papers
Abstract
Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.
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