The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
MedChemComm2012Vol. 3(9), pp. 1062–1062
Citations Over TimeTop 1% of 2012 papers
Abstract
Aqueous solubility, protein binding and CYP450 inhibition data for compounds containing a variety of heteroaromatic and heteroaliphatic rings were analysed and compared to determine which ring types fared best and worst in these developability screens. The results suggest that certain heterorings are generally more developable than others: how this information may be used and some caveats to be borne in mind are discussed.
Related Papers
- → A universal scale of aromaticity for π‐organic compounds(2009)53 cited
- → σ‐Aromaticity in an Unsaturated Ring: Osmapentalene Derivatives Containing a Metallacyclopropene Unit(2015)44 cited
- → σ Aromaticity Dominates in the Unsaturated Three‐Membered Ring of Cyclopropametallapentalenes from Groups 7–9: A DFT Study(2015)41 cited
- → Adaptive σ‐Aromaticity in an Unsaturated Three‐Membered Ring(2020)21 cited
- → Are nucleus-independent (NICS) and 1H NMR chemical shifts good indicators of aromaticity in π-stacked polyfluorenes?(2006)34 cited