On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin
MedChemComm2012Vol. 4(1), pp. 101–111
Citations Over TimeTop 15% of 2012 papers
Vincent Mascitti, Benjamin A. Thuma, Aaron Smith, Ralph P. Robinson, Thomas A. Brandt, Amit S. Kalgutkar, Tristan S. Maurer, Brian Samas, Raman Sharma
Abstract
The discovery of antidiabetic agent ertugliflozin is described. In this article, emphasis is placed on the critical role that organic synthesis played in influencing our medicinal chemistry strategy.
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