Two-, three- and four-component coupling to form isoquinolones based on directed metalation
Chemical Science2012Vol. 3(5), pp. 1450–1450
Citations Over TimeTop 14% of 2012 papers
Abstract
Benzamides undergo ortho-metalation with magnesiate bases to allow trapping with propargylic chlorides. Cyclization provides isoquinolones in a one-pot operation. Benzamides can be formed in situ from aryl Grignard reagents and isocyanates. Moreover, electrophilic trapping after cyclization introduces further complexity. Alternative cyclization conditions provide the isomeric aza-isocoumarins.
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