Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy
Chemical Communications2013Vol. 49(95), pp. 11149–11149
Citations Over TimeTop 10% of 2013 papers
Saad Makhseed, Miloslav Macháček, Waleed Alfadly, Ahmad Tuhl, Mickey Vinodh, Tomáš Šimůnek, Veronika Novakova, Pavel Kubát, Emil Rudolf, Petr Zimčík
Abstract
Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantum yield in water (ΦΔ > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 μM).
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