Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
Chemical Communications2013Vol. 49(76), pp. 8522–8522
Citations Over TimeTop 10% of 2013 papers
Swagata Banerjee, Jonathan A. Kitchen, Sandra A. Bright, John E. O’Brien, D. Clive Williams, John M. Kelly, Thorfinnur Gunnlaugsson
Abstract
The bi-functional complex [Pt(II)(terpy)(py-naphth)](NO3)2(), incorporating both 2,2':6',2''-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
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