Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate
Chemical Communications2014Vol. 50(15), pp. 1817–1819
Citations Over TimeTop 10% of 2014 papers
Abstract
The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
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