A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease
Chemical Communications2013Vol. 50(40), pp. 5301–5303
Citations Over TimeTop 10% of 2013 papers
Masha G. Savelieff, Yuzhong Liu, Russell R. P. Senthamarai, Kyle J. Korshavn, Hyuck Jin Lee, Ayyalusamy Ramamoorthy, Mi Hee Lim
Abstract
Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
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