A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?
CrystEngComm2013Vol. 15(46), pp. 9899–9899
Citations Over TimeTop 13% of 2013 papers
E. Álvarez, Alfonso García‐Márquez, Thomas Devic, Nathalie Steunou, Christian Serre, Christian Bonhomme, Christel Gervais, Isabel Izquierdo‐Barba, María Vallet‐Regí, Danielle Laurencin, Francesco Mauri, Patricia Horcajada
Abstract
A novel, biocompatible, calcium-based coordination polymer was hydrothermally synthesized using as linker the bone antiresorptive bisphosphonate alendronate. Its structure was determined using single-crystal X-ray diffraction and characterized by chemical analysis, infrared spectroscopy (IR), X-ray powder diffraction (XRPD), solid state nuclear magnetic resonance (NMR) and thermogravimetric analysis (TGA). Its bioactivity was finally evaluated in vitro, revealing a very high stability towards simulated body fluid.
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