Selective homocysteine turn-on fluorescent probes and their bioimaging applications
Chemical Communications2014Vol. 50(53), pp. 6967–6967
Citations Over TimeTop 1% of 2014 papers
Hye Yeon Lee, Yoon Pyo Choi, Sun Kyung Kim, Tae‐Jin Yoon, Zhiqian Guo, Songyi Lee, K.M.K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon
Abstract
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
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