Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)–H bonds with aryl halides
Chemical Communications2014Vol. 50(30), pp. 3944–3946
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Abstract
In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp(3))-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp(3))-H bond arylation.