The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide
Chemical Communications2014Vol. 50(49), pp. 6475–6478
Citations Over TimeTop 10% of 2014 papers
Abstract
A rationally designed small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism has been developed. Attaching a NO-responsive dihydropyridine pendant group to a fluorophore led to a probe that displays a very high sensitivity to NO concentrations down to the low nM range and a very high specificity to NO while being insensitive to other oxidative oxygen/nitrogen species that often interfere with the sensing of NO.
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