Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix
Chemical Communications2014Vol. 50(39), pp. 5027–5030
Citations Over TimeTop 11% of 2014 papers
Abstract
We report the design of side-chain-to-tail linked organo-peptide hybrids incorporating an α-helical protein-binding motif. Using this strategy, macrocyclic inhibitors of the p53:HDM2 interaction displaying dual specificity against the HDMX homolog as well as increased proteolytic stability could be obtained.
Related Papers
- → Properties of Known Drugs. 2. Side Chains(1999)280 cited
- → The Influence of the Amino Acid Side Chains on the Raman Optical Activity Spectra of Proteins(2018)12 cited
- → Erratum to ‘‘Addition of side chains to a known backbone with defined side-chain centroids’’(2003)4 cited
- → Determinants of protein side‐chain packing(1994)60 cited
- → Synthesis and Characterization of Urethane Side Chain Substituted Diketopyrrolopyrrole(2021)