Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells
Chemical Communications2014Vol. 50(94), pp. 14724–14727
Citations Over TimeTop 15% of 2014 papers
Ming Cheng, Wei Zhang, Jinghe Yuan, Wangxi Luo, Nan Li, Shixian Lin, Yi Yang, Xiaohong Fang, Peng R. Chen
Abstract
We achieved single-molecule imaging and tracking of the transforming growth factor type II receptor (TβRII) that was labeled by an organic dye via a genetically encoded unnatural amino acid (UAA) and the copper-free click chemistry. The stoichiometry, mobility and dimerization kinetics of individual TβRII molecules were determined.
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