MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery
Chemical Communications2014Vol. 51(3), pp. 465–468
Citations Over TimeTop 10% of 2014 papers
Wei‐Hai Chen, Guo‐Feng Luo, Qi Lei, Huizhen Jia, Sheng Hong, Qingrong Wang, Ren‐Xi Zhuo, Xian‐Zheng Zhang
Abstract
Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
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