(E)-α,β-unsaturated amides from tertiary amines, olefins and CO via Pd/Cu-catalyzed aerobic oxidative N-dealkylation
Chemical Communications2015Vol. 51(15), pp. 3247–3250
Citations Over TimeTop 10% of 2015 papers
Renyi Shi, Hua Zhang, Lijun Lu, Pei Gan, Yuchen Sha, Heng Zhang, Qiang Liu, Matthias Beller, Aiwen Lei
Abstract
A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed. Tertiary amines are utilized as a "reservoir" of "active" secondary amines in this transformation, which inhibits the formation of undesired by-products and the deactivation of the catalysts. This protocol allows for an efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives from easily available tertiary amines, olefins and CO.
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