The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction
Chemical Communications2015Vol. 51(42), pp. 8789–8792
Citations Over TimeTop 10% of 2015 papers
Mingxia Ma, Yuan‐Yuan Zhu, Quantao Sun, Xiaoyuan Li, Jinhuan Su, Long Zhao, Yanyan Zhao, Shuai Qiu, Wenjin Yan, Kairong Wang, Rui Wang
Abstract
A new strategy for the construction of optically active 5'-CF3 spiro[pyrrolidin-3,2'-oxindole] was described. A series of unprecedented 1,3-dipoles were obtained by condensation of CF3CH2NH2 with isatins. The 1,3-dipolar cycloaddition reactions of these ketimines with enals gave the products bearing four contiguous stereogenic centers in excellent yields, diastereoselectivities and enantioselectivities.
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