Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides
Chemical Communications2015Vol. 51(41), pp. 8652–8655
Citations Over TimeTop 23% of 2015 papers
Ruei‐Yu He, Yichen Huang, Chao‐Wei Chiang, Yu-Ju Tsai, Ting-Juan Ye, Hua‐De Gao, Chu-Ya Wu, Hsien‐Ming Lee, Joseph Jen‐Tse Huang
Abstract
We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.
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