Mechanism of DNA assembly as revealed by energy barriers
Chemical Communications2015Vol. 51(36), pp. 7717–7720
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Abstract
The mechanism of DNA assembly is revealed by analyzing the energy barriers during nucleation and growth. The assembly is controlled by two competing parameters: the conformation adjustment rate of DNA strands and the spreading rate of new strands on the nuclei surface, both of which are temperature dependent and can be tuned by sequence design.
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