A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyrans via double direct C–F substitutions
Chemical Communications2015Vol. 51(39), pp. 8326–8329
Citations Over TimeTop 10% of 2015 papers
Jieru Yang, Ao Mao, Zhenting Yue, Wenxuan Zhu, Xuewei Luo, Chuwei Zhu, Yuanjing Xiao, Junliang Zhang
Abstract
A straightforward and efficient approach to structurally diverse and synthetically useful ring-fluorinated 4H-pyrans via a simple base-mediated cascade reaction of readily available trifluoromethylated alkenes with 1,3-dicarbonyl compounds was developed. The key events of this reaction involve two consecutive C-F substitutions under very mild conditions.
Related Papers
- → Multiple‐Organocatalyst‐Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted Piperidines(2010)104 cited
- → 6.13 C–C Bond Formation: Cascade or Domino Reaction(2012)7 cited
- → InCl3-Mediated Cascade Reactions for the Construction of Highly Functionalized 1-Oxadecalins(2007)6 cited
- → ChemInform Abstract: Alternating Iodonium‐Mediated Reaction Cascades Giving Indole‐ and Quinoline‐Containing Polycycles.(2008)
- → ChemInform Abstract: Efficient Synthesis of Tetrahydronaphthalene‐ or Isochroman‐Fused Spirooxindoles Using Tandem Reactions.(2016)