An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite
CrystEngComm2016Vol. 18(9), pp. 1486–1488
Citations Over TimeTop 10% of 2016 papers
Tarek A. Zeidan, Jacob T. Trotta, Pranoti A. Tilak, Mark A. Oliveira, Renato A. Chiarella, Bruce M. Foxman, Örn Almarsson, Magali B. Hickey
Abstract
A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.
Related Papers
- → Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite(2011)39 cited
- → Clopidogrel variability: role of plasma protein binding alterations(2012)14 cited
- → Pharmacologically Active Drug Metabolites(1976)91 cited
- → Disposition of Pentopril, a New Orally Active Angiotensin-Converting Enzyme Inhibitor, and Its Active Metabolite in Rats(1985)7 cited
- → Pharmacokinetic Relationships Between Cinromide and Its Metabolites in the Rhesus Monkey I: 3-Bromocinnamamide, an Active Metabolite(1983)4 cited