Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity
Chemical Communications2016Vol. 53(4), pp. 783–786
Citations Over TimeTop 11% of 2016 papers
Abstract
We report a new turn-on substrate probe whose intense fluorescent reporter signature is selectively provided upon probe activation by the cancer-associated oxidoreductase, hNQO1. The extremely high fluorescence turn-on of the probe was utilized to generate fluorescence microscope images of hNQO1-expressing, tumor-derived colorectal and ovarian cancer cells with unprecedented positive signal-to-negative background ratios (PNRs), a key step toward probe application in guided surgical removal of diseased tissues.
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