Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis
Chemical Society Reviews2017Vol. 46(8), pp. 2272–2305
Citations Over TimeTop 10% of 2017 papers
Abstract
1,2-Carbon atom rearrangement has been broadly applied as a guiding strategy in complex molecule assembly. As it entails the carbon-carbon or carbon-heteroatom bond migration between two vicinal atoms, this type of reaction is capable of generating structural complexity through a molecular skeletal reorganization. This review will focus on recent employment of this strategy in the total synthesis of natural products, highlighting the exceptional utility of such synthetic methodologies in the construction of intricate carbocycles, heterocycles or structurally complex motifs from synthetically more accessible precursors.
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