Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels
Chemical Communications2017Vol. 53(23), pp. 3350–3353
Citations Over TimeTop 10% of 2017 papers
Asja Pettignano, Santiago Grijalvo, Marleen Häring, Ramón Eritja, Nathalie Tanchoux, Françoise Quignard, David Díaz Díaz
Abstract
One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.
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