Peptide array functionalization via the Ugi four-component reaction
Chemical Communications2017Vol. 53(40), pp. 5553–5556
Citations Over TimeTop 24% of 2017 papers
Abstract
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.
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