Dendrimers in combination with natural products and analogues as anti-cancer agents
Chemical Society Reviews2017Vol. 47(2), pp. 514–532
Citations Over TimeTop 1% of 2017 papers
Serge Mignani, João Rodrigues, Helena Tomás, Maria Zabłocka, Xiangyang Shi, Anne‐Marie Caminade, Jean‐Pierre Majoral
Abstract
For the first time, an overview of dendrimers in combination with natural products and analogues as anti-cancer agents is presented. This reflects the development of drug delivery systems, such as dendrimers, to tackle cancers. The most significant advantages of using dendrimers in nanomedicine are their high biocompatibility, good water solubility, and their entry - with or without encapsulated, complexed or conjugated drugs - through an endocytosis process. This strategy has accelerated over the years in order to develop nanosystems as nanocarriers, to decrease the intrinsic toxicity of anti-cancer agents, to decrease the drug side effects, to increase the efficacy of the treatment, and consequently to improve patient compliance.
Related Papers
- → The dendritic effect illustrated with phosphorus dendrimers(2014)129 cited
- Dendrimers in medicine and biotechnology. New molecular tools(2006)
- → Force Biased Molecular Dynamics Simulation Study of Effect of Dendrimer Generation on Interaction with DNA(2012)25 cited
- → An alternative convergent synthesis of dendrimers with 2,5-diarylsilole at the core(2007)17 cited
- → Syntheses of Dendrimers and Dendrons(2011)6 cited