Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy
Chemical Communications2018Vol. 54(16), pp. 1996–1999
Citations Over TimeTop 15% of 2018 papers
Abstract
We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.
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