A 2-(1-methylhydrazinyl)pyridine-directed C–H functionalization/spirocyclization cascade: facile access to spirosuccinimide derivatives
Chemical Communications2018Vol. 54(39), pp. 4927–4930
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Hua Zhao, Xiaoru Shao, Taimin Wang, Shengxian Zhai, Shuxian Qiu, Tao Cheng, Huifei Wang, Hongbin Zhai
Abstract
A cobalt-catalyzed oxidative coupling of benzoic hydrazides with maleimides by utilizing 2-(1-methylhydrazinyl)pyridine as a bidentate directing group has been developed. This C-H functionalization/spirocyclization cascade protocol shows high efficiency and remarkable functional group tolerance, and the ubiquitous spirosuccinimides were obtained in good to excellent yields with high regioselectivity. This strategy also provides a novel and efficient access to diverse symmetric and unsymmetrical bisspirosuccinimides.
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