Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia
Chemical Communications2018Vol. 54(50), pp. 6939–6942
Citations Over TimeTop 11% of 2018 papers
Kenjiro Hanaoka, Yu Kagami, Wen Piao, Takuya Myochin, Koji Numasawa, Yugo Kuriki, Takayuki Ikeno, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano, Yasuteru Urano
Abstract
Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.
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