Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
Physical Chemistry Chemical Physics2018Vol. 20(15), pp. 9755–9759
Citations Over TimeTop 10% of 2018 papers
Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso‐Valdesueiro, Lyndon Emsley, Sami Jannin, Malcolm H. Levitt
Abstract
Monodeuterated methyl groups may support a long-lived nuclear spin state, with a relaxation time exceeding the conventional spin-lattice relaxation time T1. Dissolution-DNP (dynamic nuclear polarization) may be used to hyperpolarize such a long-lived spin state. This is demonstrated for the CH2D groups of a piperidine derivative. The polarized sample is manipulated in the ambient magnetic field of the laboratory, without destruction of the hyperpolarized singlet order. Strongly enhanced CH2D signals are observed more than one minute after dissolution, even in the presence of paramagnetic radicals, by which time the NMR signal from the hyperpolarized proton magnetization has completely disappeared.
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