Crystallomycin revisited after 60 years: aspartocins B and C
MedChemComm2018Vol. 9(4), pp. 667–675
Citations Over Time
Anton P. Tyurin, Vera A. Alferova, Alexander S. Paramonov, Maxim V. Shuvalov, I.A. Malanicheva, Natalia E. Grammatikova, Pavel N. Solyev, Shaowei Liu, Cheng‐Hang Sun, Igor A. Prokhorenko, Tatiana A. Efimenko, Larisa P. Terekhova, Olga V. Efremenkova, Захар О. Шенкарев, Vladimir A. Korshun
Abstract
The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed that two major components of the antibiotic, compounds 1 and 2, are lipopeptides having the same peptide core, Asp1-cyclo(Dab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), N-acylated either with Δ3-iso-tetradecenoyl or Δ3-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively. According to the 2D NMR study, compound 2 in DMSO solution exists as a mixture of four conformers. The producing strain was identified as Streptomyces griseorubens. Compounds 1 and 2 have considerable Ca2+-dependent activity against Gram-positive bacteria including five MRSA strains.
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