Diversity of PEGylation methods of liposomes and their influence on RNA delivery
MedChemComm2019Vol. 10(3), pp. 369–377
Citations Over TimeTop 10% of 2019 papers
A. S. Nosova, О. О. Колоскова, Alexandra Nikonova, V. A. Simonova, Smirnov Vv, D.А. Kudlаy, Musa Khaitov
Abstract
Gene therapy is a promising approach for personalized medicine, but its application in humans requires development of efficient and safe vehicles. PEGylated liposomes are some of the most suitable delivery systems for nucleic acids because of their stability under physiological conditions and prolonged circulation time, compared to conventional and other types of "stealth" liposomes. In vitro/in vivo activity of PEGylated liposomes is highly dependent on PEG motif abundance. The process of "stealth" coverage formation is a very important parameter for efficient transfection assays and further fate determination of the PEG layer after tissue penetration. In this review, we discuss the latest methods of PEGylated liposome preparation.
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