Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol
Organic & Biomolecular Chemistry2018Vol. 16(39), pp. 7170–7173
Citations Over TimeTop 13% of 2018 papers
Abstract
Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
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