Investigations into the DNA-binding mode of doxorubicinone
Organic & Biomolecular Chemistry2018Vol. 17(7), pp. 1992–1998
Citations Over TimeTop 18% of 2018 papers
Samuel S. Tartakoff, Jennifer M. Finan, Ellis J. Curtis, Haley M. Anchukaitis, Danielle J. Couture, Samantha Glazier
Abstract
Cancer treatment is one of the major challenges facing the modern biomedical profession. Development of new small-molecule chemotherapeutics requires an understanding of the mechanism of action for these treatments, as well as the structure-activity relationship. Study of the well-known DNA-intercalating agent, doxorubicin, and its aglycone, doxorubicinone, was undertaken using a variety of spectroscopic and calorimetric techniques. It was found that, despite conservation of the planar, aromatic portion of doxorubicin, the agylcone does not intercalate; it instead likely binds to the DNA minor-groove.
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