A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid

Citations Over TimeTop 11% of 2018 papers

Abstract

Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Furthermore, the probe L is biocompatible, cell-membrane permeable and mitochondria-targetable, and can be used for endogenous HOCl imaging in living cells.

Related Papers

• → Cysteine recognition by a benzothiazole-derived fluorescent probe with “AIE+ESIPT” characteristics(2022)51 cited
• → Construction of red-emitting iminocoumarin-based fluorescent borate complexes with a large Stokes shift(2019)8 cited
• → Development of New Pyrrolocoumarin Derivatives with Satisfactory Fluorescent Properties and Notably Large Stokes Shifts(2008)38 cited
• → An activatable fluorescent probe with an ultrafast response and large Stokes shift for live cell bioimaging of hypochlorous acid(2016)10 cited
• → N-quaternization of heterocyclic compound extended the emission to NIR with large Stokes shift and its application in constructing fluorescent probe(2021)8 cited