New insights into the metal-induced oxidative degradation pathways of transthyretin
Chemical Communications2019Vol. 55(28), pp. 4091–4094
Citations Over TimeTop 16% of 2019 papers
Michael L. Poltash, Mehdi Shirzadeh, Jacob W. McCabe, Zahra Moghadamchargari, Arthur Laganowsky, David H. Russell
Abstract
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.
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