Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging
Chemical Communications2019Vol. 55(31), pp. 4582–4585
Citations Over TimeTop 10% of 2019 papers
Lucie Plougastel, Manas R. Pattanayak, Margaux Riomet, Sarah Bregant, Antoine Sallustrau, Marc Nothisen, Alain Wagner, Davide Audisio, Frédéric Taran
Abstract
We report the synthesis and use of sydnone-based profluorophores as tools for imaging applications. These new probes display exquisite reactivity towards strain promoted cycloaddition reactions with cycloalkynes allowing fast, efficient and selective labeling in biological media. Styryl-pyridinium sydnone probes were found particularly interesting for click reactions to proceed selectively inside cells.
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