Enhanced cis - and enantioselective cyclopropanation of styrene catalysed by cytochrome P450BM3 using decoy molecules
Chemical Communications2020Vol. 56(75), pp. 11026–11029
Citations Over TimeTop 24% of 2020 papers
Abstract
We report the enhanced cis- and enantioselective cyclopropanation of styrene catalysed by cytochrome P450BM3 in the presence of dummy substrates, i.e. decoy molecules. With the aid of the decoy molecule R-Ibu-Phe, diastereoselectivity for the cis diastereomers reached 91%, and the enantiomeric ratio for the (1S,2R) isomer reached 94%. Molecular dynamics simulations underpin the experimental data, revealing the mechanism of how enantioselectivity is controlled by the addition of decoy molecules.
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