Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediates
Green Chemistry2020Vol. 22(20), pp. 6809–6814
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Tianzhen Li, Zijing Tang, Hongli Wei, Zijian Tan, Pi Liu, Jinlong Li, Yingying Zheng, Jianping Lin, Weidong Liu, Huifeng Jiang, Haifeng Liu, Leilei Zhu, Yanhe Ma
Abstract
A green chemoenzymatic reaction converts C1 compound formaldehyde into lactic acid using a newly identified formolase variant and NaOH as catalysts.
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